Ca-induced Ca release mechanism in vascular smooth muscle
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چکیده
منابع مشابه
Intracellular Ca release in skinned smooth muscle
The release of internal Ca from saponin-treated skinned smooth muscle of guinea pig taenia caecum was studied. The amount of Ca released was estimated by the area under the contraction curve during treatment with 25 mM caffeine in the presence of 0.1 mM EGTA. The magnitude of the caffeine response in skinned muscle, after loading with 10(-6) M Ca for 3 min, was similar to that in the depolarize...
متن کاملStretch-induced Ca signalling in vascular smooth muscle cells depends on Ca store segregation
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Stretch-induced Ca signalling in va...
متن کاملSarcoplasmic Reticulum Ca Refilling Controls Recovery From Ca -Induced Ca Release Refractoriness in Heart Muscle
In cardiac muscle Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) is initiated by Ca influx via L-type Ca channels. At present, the mechanisms underlying termination of SR Ca release, which are required to ensure stable excitation-contraction coupling cycles, are not precisely known. However, the same mechanism leading to refractoriness of SR Ca release could also be responsi...
متن کاملNa-Ca Exchange in Cultured Vascular Smooth Muscle Cells
Vascular smooth muscle cells (VSMC) contract as intracellular free calcium ([Ca],) rises. While Na-Ca exchange has been proposed to contribute to transmembrane Ca flux, its role in cultured VSMC is unknown. Accordingly, we have investigated the role of Na-Ca exchange in unidirectional and net transmembrane Ca fluxes in cultured rat aortic VSMC under basal conditions and following agonist-mediat...
متن کاملCa(2+) oscillations, gradients, and homeostasis in vascular smooth muscle.
Vascular smooth muscle shows both plasticity and heterogeneity with respect to Ca(2+) signaling. Physiological perturbations in cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) may take the form of a uniform maintained rise, a transient uniform [Ca(2+)](i) elevation, a transient localized rise in [Ca(2+)](i) (also known as spark and puff), a transient propagated wave of localized [Ca(2+)](i) elev...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53968-3